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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HDAC1
All Species:
54.55
Human Site:
T189
Identified Species:
80
UniProt:
Q13547
Number Species:
15
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13547
NP_004955.2
482
55103
T189
G
V
E
E
A
F
Y
T
T
D
R
V
M
T
V
Chimpanzee
Pan troglodytes
XP_519834
482
55098
T189
G
V
E
E
A
F
Y
T
T
D
R
V
M
T
V
Rhesus Macaque
Macaca mulatta
XP_001096929
485
54378
T198
G
V
E
E
A
F
Y
T
T
D
R
V
M
T
V
Dog
Lupus familis
XP_544435
482
55144
T189
G
V
E
E
A
F
Y
T
T
D
R
V
M
T
V
Cat
Felis silvestris
Mouse
Mus musculus
O09106
482
55056
T189
G
V
E
E
A
F
Y
T
T
D
R
V
M
T
V
Rat
Rattus norvegicus
Q4QQW4
482
55074
T189
G
V
E
E
A
F
Y
T
T
D
R
V
M
T
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521848
455
51607
T186
G
V
E
E
A
F
Y
T
T
D
R
V
M
T
V
Chicken
Gallus gallus
P56517
480
54920
T189
G
V
E
E
A
F
Y
T
T
D
R
V
M
T
V
Frog
Xenopus laevis
O42227
480
54874
T189
G
V
E
E
A
F
Y
T
T
D
R
V
M
S
V
Zebra Danio
Brachydanio rerio
Q803C3
428
48962
R163
E
L
L
K
Y
H
P
R
V
L
Y
I
D
I
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q94517
521
58312
T187
G
V
E
E
A
F
Y
T
T
D
R
V
M
T
V
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
O17695
461
52119
T193
G
V
E
E
A
F
Y
T
T
D
R
V
M
T
V
Sea Urchin
Strong. purpuratus
P56518
576
64060
T188
G
V
E
E
A
F
Y
T
T
D
R
V
M
T
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P56521
513
57528
T202
G
V
E
E
A
F
Y
T
T
D
R
V
M
T
V
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O22446
501
56004
A197
G
V
E
E
A
F
Y
A
T
D
R
V
M
T
V
Baker's Yeast
Sacchar. cerevisiae
P32561
433
48886
I170
L
N
D
I
V
L
G
I
I
E
L
L
R
Y
H
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
88.4
99.1
N.A.
99.3
99.1
N.A.
83.4
93.3
91
54.3
N.A.
71.9
N.A.
59.5
69.6
Protein Similarity:
100
100
90.7
99.5
N.A.
100
100
N.A.
89
96.4
96.8
71.3
N.A.
82.1
N.A.
77.5
77.4
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
100
100
93.3
0
N.A.
100
N.A.
100
100
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
100
100
20
N.A.
100
N.A.
100
100
Percent
Protein Identity:
N.A.
53.2
N.A.
56.6
54.5
N.A.
Protein Similarity:
N.A.
69.9
N.A.
71
70.1
N.A.
P-Site Identity:
N.A.
100
N.A.
93.3
0
N.A.
P-Site Similarity:
N.A.
100
N.A.
93.3
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
88
0
0
7
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
7
0
0
0
0
0
0
88
0
0
7
0
7
% D
% Glu:
7
0
88
88
0
0
0
0
0
7
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
88
0
0
0
0
0
0
0
0
0
% F
% Gly:
88
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
7
% H
% Ile:
0
0
0
7
0
0
0
7
7
0
0
7
0
7
0
% I
% Lys:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
7
7
7
0
0
7
0
0
0
7
7
7
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
88
0
0
% M
% Asn:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
7
0
0
88
0
7
0
0
% R
% Ser:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% S
% Thr:
0
0
0
0
0
0
0
82
88
0
0
0
0
82
0
% T
% Val:
0
88
0
0
7
0
0
0
7
0
0
88
0
0
88
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
7
0
88
0
0
0
7
0
0
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _